ARVO 2010 Abstracts - Glaucoma

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Several presentations at the ARVO meeting represented the continuing endeavor to better understand the risk factors and pathophysiology of dry eye. Japan's Murat Dogru, MD, and colleagues demonstrated the role of dehydration in dry eye by comparing subjects drinking a controlled amount of alcohol n: Twelve hours after alcohol intake, substantial detrimental changes were observed in tear-function metrics e.

These results suggest substantial effects of alcohol on tear function. Dogru M, et al. Research efforts to enhance the understanding of the intricate relationship between visual function, blinking and dry eye were present in abundance across different groups of scientists and clinicians.

CFC1 Bibliography of Publications and Abstracts

Researchers from SUNY College of Optometry demonstrated increased symptomatology following computer use compared to that reported after hard-copy fixation in a study of 24 participants. While these findings correlated to ocular surface disease severity, there was no apparent correlation to decreased blink rate. Chu CA , et al. ARVO E-abstract Our group presented results of its studies using customized video processing methodology to decipher blink patterns in dry-eye patients and normals, as well as to quantify the amount of corneal exposure which occurs between blinks in a new metric called the time-area Ocular Protection Index.

White R, et al. Clinical research models and results of clinical trials of developing therapies were also presented. Our group presented exciting data using the Enhanced Controlled Adverse Environment system, which has been used in a number of clinical trials in recent years, and represents the precision possible when using honed diagnostics and clinical trial design features.

Ousler GW, et al. Hsu H-C, et al. Komuro A, et al. ARVO E-abstract Finally, another study presented results of an ophthalmic anionic lipid emulsion containing HP-Guar, demonstrating potential as a novel artificial tear. Ketelson HA, et al.

A Look Back at the ARVO Meeting

In addition, a few intriguing examples of preclinical research with potential clinical application in the future emerged. Lubricin—a glycoprotein found in the cartilage of the knee—demonstrated reduced friction and tissue wear when tested using biomechanical machinery and human corneas and eyelids, which may suggest an advantage as an ocular surface lubricant. Schmidt TA, et al. ARVO E-abstract One group of researchers presented intriguing results of a mouse study demonstrating the potential of both vitamin D and its active metabolite 1, OH 2D to improve corneal epithelial barrier function, which may suggest clinical applications with further research.

Watsky MA, et al. Finally, prior to ARVO, expert clinical researchers, scientists, regulators, pharmaceutical executives, and venture capitalists interested in dry eye convened at the Dry Eye Summit, an event co-sponsored by our pharmaceutical consulting firm, Ora. Topics presented ranged from the history of dry eye, to defining dry eye, to clinical regulatory and exit strategies.

The summit imparted a business and regulatory spin to the discussion of innovations in dry-eye therapy. In a preclinical study, the combination of dexamethasone and povidone-iodine 0. FST reduced viral titers significantly more than placebo or Tobradex when all were applied q.

Titer reductions with FST were comparable with those seen with twice daily cidofavir 0. Animals were also scored for symptoms such as conjunctival and eyelid inflammation, exudates, excessive tearing and corneal neovascularization. The FST group had significantly lower scores i. Hill JM, et al. Besifloxacin was comparable to moxifloxacin and ciprofloxacin against H. Haas W, et al. As part of the body's natural defense against infection, granulocytes and monocytes produce NCT, a compound with anti-inflammatory and anti-infective activity.

NovaBay scientists examined the chemical stability, anti-microbial and antiviral activity of NVC in the presence of artificial tears. Najafi KK, et al. Romanowski EG, et al. ARVO E-abstract They used a rabbit model of ocular viral infection to show that ALA can significantly reduce the duration and severity of ocular infections. Gordon YJ, et al.

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ARVO E-abstract While it wasn't as effective as the positive control cidofovir , it displayed little of the toxicity associated with currently available antiviral drugs, including cidofovir. Researchers reported interim results from a multicenter, open-label trial examining anti-TNF antibody adalimumab Humira, Abbott as a therapy for refractory uveitis. Treatment involved a 40 mg sc injection every two weeks and assessment of safety and efficacy over a week trial.

Inclusion in the study required diagnosis of noninfectious uveitis refractory to corticosteroids and at least one immunosuppressive. Endpoints included acuity improvement, de--creased intraocular inflammation and steroid tapering. Seventeen of 26 patients who completed the week trial responded positively to therapy, and 15 of these continued with treatment for 50 weeks. One initial responder discontinued treatment due to a loss of efficacy, and the only significant adverse event was unrelated to adalimumab.

Salom D, et al. Several other trials examined the use of monoclonal antibody mAb therapy targeting other immuno-modulators. Most of these agents were originally developed to treat systemic disorders but they have significant therapeutic potential in ocular inflammatory disease. An open-label study tested AIN, a humanized monoclonal directed against IL, for patients with noninfectious uveitis. Efficacy variables included acuity, vitreous haze, anterior chamber inflammation and reduction of corticosteroid dosing. Eight of 11 patients 73 percent with posterior segment uveitis and three of five patients 60 percent with anterior uveitis met the response criteria in this study.

Only one patient showed no response and required prednisone rescue.

Samson CM, et al. ARVO E-abstract Another study examined safety and efficacy of rituximab, an anti-CD mAb developed to treat B-cell lymphomas, for refractory scleritis and non-infective orbital inflammation. A total of 15 patients received rituximab infusion or 1, mg on days one and 15 of the study; followed by monthly safety monitoring and efficacy assessment at 24 and 48 weeks. The overall outcome was positive: Four patients were able to taper steroid dosing, and only one patient required increased steroids.

Vision was stable or improved in 14 patients, and patient and physician global health assessments also improved. The only significant safety issue involved seven of the first nine patients treated; they experienced inflammatory exacerbations after infusion that required adjunctive corticosteroids.

This didn't occur in the remaining six patients, nor has it occurred in the patients that have been re-infused since then. Successful panretinal photocoagulation leads to changes in the retinal venular vascular geometry in patients with proliferative diabetic retinopathy. Self-help, lifestyle and awareness influence sight-threatening retinopathy in patients attending diabetic eye clinics in India and Nepal Open Access.

Early retinal changes in Optical Coherence Tomography in patients with type 1 diabetes under intensified insulin therapy Open Access. Real-life visual and anatomical outcomes with fluocinolone acetonide FAc and cumulative cost of treatment in the treatment of chronic diabetic macular edema DME Open Access. Retinal oxygen saturation is an independent contributor to the severity of retinopathy in diabetic patients Open Access. Parafoveal OCT angiography features in diabetic patients without clinical diabetic retinopathy: Patient comfort using green nm versus yellow nm panretinal photocoagulation with the laser indirect ophthalmoscope for proliferative diabetic retinopathy Open Access.

The need for early retinopathy screening and improved awareness in diabetic patients in Hangzhou, China. The region-dependent neovascularization and macular layer-specific edema and ischemia in proliferative diabetic retinopathy Open Access.

A Look Back at the 2010 ARVO Meeting

Correlation of total HbA1c load with prevalence of diabetic retinopathy among type 1 diabetic patients treated with intensified insulin therapy from the onset of disease Open Access. Ploner; Carl B Rebhun; A. Efficacy and safety of Fluocinolone acetonide implant use for the treatment of refractory diabetic macular oedema and its impact on the hospital diabetic eye services Open Access. Comparison of efficacy of intravitreal versus sub-Tenon injection of triamcinolone acetonide during cataract surgery for diabetic macular edema Open Access.

Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice Open Access. One-year safety outcomes of intravitreal implant of fluocinolone acetonide 0. Reduced foveal thickness correlates with depressed foveal visual function in eyes with diabetic retinopathy Open Access. Quantification of retinal nonperfusion associated with neovascularization in diabetic retinopathy using ultrawide field fluorescein angiography Open Access. Opening the Black Box: Huang; Caroline Yu; Robert A. Evaluation and referral of diabetic eye disease within the endocrinology and primary care office setting: A quality improvement project Open Access.

Cecilia Lansang; Rishi P Singh. Advanced Glycation Endproducts in capsulorhexis specimen: Correlation with Diabetic Retinopathy. Variability of retinal layer thicknesses within diabetic subjects Open Access. Switching corticosteroids therapy for diabetic macular edema Open Access. Outer retinal changes in patients with diabetes and no or mild non-proliferative diabetic retinopathy Open Access.

Sustained release intravitreal dexamethazone implant in the treatment of proliferative diabetic retinopathy and diabetic macular edema Open Access. Severe retinal dysplasia and detachment in mice lacking Maturin Open Access. Immature photoreceptor layer and inner retinal layers in full term neonates identified with optical coherence tomography Open Access. The effect of rhythmic activity on neurite outgrowth of developing retinal explants in rd1 mice Open Access.

Elucidating the roles of homeodomain transcription factors Six3 and Six6 in retinal differentiation Open Access. Characterization of zebrafish her9 regulation and function in retinal development Open Access. Temporal and spatial inhibition of Mab21L2 as a model system for coloboma and anophhtalmia Open Access.

Loss of Macf1 abolishes ciliogenesis and disrupts apicobasal polarity establishment in the retina Open Access. Characterization of Capn5 expression and function in the zebrafish retina Open Access. Identification and characterization of long noncoding RNAs in retinal progenitor cell competence Open Access. Age-dependent post-translational modification of neuronal activity-regulated pentraxin Narp in the mouse retina Open Access. Ushananthini Shanmugalingam; Abigail E. Dopamine is an Opsin 5-dependent modulator of vascular development in the eye Open Access.

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  4. Identification of an enhancer that regulates Otx2 expression during early retinal differentiation Open Access. Cell cycle gene reactivation in rd1 mouse retina prior to degeneration Open Access. Retinoic acid engineered amniotic membrane used as a graft or homogenates: Sphingolipids in the Human Cornea, to boldly go where no one has gone before Open Access. Novel approaches to anchoring therapeutic factors to corneal stroma to promote wound healing. Evaluating the effect of hyaluronic acid-containing artificial tear products on corneal wound re-epithelialization in an in vivo preclinical study.

    Effect of ST, an amnion-derived multipotent progenitor cell-derived secretome, in a corneal incision model for post-operative inflammation Open Access. Alginate-encapsulated adipose-derived stem cells: Semaphorin3A is an inducer of neuronal growth and nerve regeneration in adult corneas. Transparency of suture able, nanofiber reinforced, alginate hydrogels for corneal wound healing Open Access. Expression in the cornea and its role in corneal wound healing Open Access.

    The effect of human growth hormone on corneal wound healing in mice Open Access. Growth of human corneal epithelial cell on silk films with different nanotopographies. Optimized gene therapy normalizes wound healing and stem cell marker expression in cultured diabetic limbal epithelial cells. Effect of conditioned medium on corneal epithelial cells wound healing in vitro Open Access.

    Influence of the molecular weight on the suture retention properties of polycaprolactone Open Access. Mice gender and strain affect neurotrophin secretion and corneal nerve regeneration after injury Open Access. Potential role of topical bovine colostrum in remodeling corneal epithelial cells after an acute ocular alkali burn in mice Open Access. Corneal Keratocytes Open Access. Corneal wound healing mechanisms modulated by novel antimicrobial peptides Open Access. Anne Kasus-Jacobi; Amanda J. Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal wound healing Open Access.

    An ex vivo model using porcine eyeballs for wound healing studies Open Access. Corneal woundhealing model employing a bioreactor Open Access. Outcomes of multiple-dose fibrin glue during in-office pterygiectomy Open Access. Gregory A Hutcheson; David O. Interleukin-6 expression in an ex vivo model of equine corneal wound healing Open Access.

    Thermal injuries of the cornea: Injury patterns and histopathology Open Access. Genetic, environmental and phenotypic risk factors for progression of age-related macular degeneration Open Access. Getting to the root of MacTel: Incidence and de-novo mutation rate of Marfan syndrome and risk of ectopia lentis Open Access. Heritability of retinal vascular fractals: Newly identified genes for refractive error and risk of myopia Open Access. European ancestry is associated with lower risk of primary open angle glaucoma in Latinos Open Access. Genetic heritability and associations of Pigmentary Glaucoma Open Access.

    The Amish Eye Study: Systemic Effects of AAV. H suppresses neovascularization through inhibition of secretion of VEGF and proliferation of vascular endothelial cells Open Access. The efficacy of aflibercept in treating retinopathy of prematurity in the mouse model of oxygen-induced retinopathy Open Access.

    Clay Smith; Jade Gieseke Guevara. Blockade of Apelin Receptor APJ can inhibit developmental retinal vessel outgrowth in pups and promote normal revascularization and reduce pathological neovascularization in OIR model i Therapeutic potential of topical administration of H, an isoquinoline sulfonamide derivative, in wet AMD and proliferative diabetic retinopathy Open Access. The long leap from drug affinity to efficacy: Intervening factors that strongly influence clinical outcomes Open Access.

    Panobinostat reduces neovascularization in an alkali-induced corneal injury model Open Access. Anti-VEGF induced nephropathy following intravitreal administration: Effects of anti-angiogenic drugs on expression patterns of genes involved in different AMD pathogenetic pathways Open Access. Tarek Moustafa; Shari R. Ciliary neurotrophic factor in patients with age-related cataract Open Access.

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    8. Surface analytical studies of growth factor coupling to collagen by copper-free click chemistry Open Access. An increased expression of IL and Foxp3 is observed in contrast to other Th genes in primary pterygium Open Access. Quantification of aflibercept and ranibizumab efficacy in DLaminoadipic acid DLAAA -induced retinal neovascularization and vascular leakage in nonhuman primates Open Access. Comparison of pain and comfort for intravitreal administration of anti-VEGF agents using blepharostat vs non blepharostat techniques.

      Increased levels of nitric oxide may pathologically affect functional hyperemia in the retina: Treatment outcomes of chronic central serous retinopathy in women compared to men Open Access. Microelectrode penetration of the wall of porcine retinal arterioles in vitro results in recordings from at least two different cell types. Mouse retina is amenable to cholesterol lowering by a statin Open Access.

      Impaired retinal signal transmission in simvastatin fed mice Open Access. One year retrospective analysis of ocriplasmin for the treatment of symptomatic vitreomacular traction Open Access. Effect of exogenous carotenoids on retinal pigment epithelium cells Open Access. Post-hypoxic recovery of the diameter of retinal arterioles is impaired in diabetic patients without retinopathy. Cost effectiveness of Intravitreal Ocriplasmin for vitreomacular adhesion and macular hole Open Access. Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina Open Access.

      Modulation of electrical activity in the retina of the rd10 mouse model using neuroprotective drugs Open Access. Identification of a novel small molecule chaperon of rhodopsin and its therapeutic potential in retinal degeneration Open Access. Preclinical results of a new pharmacological therapy approach for Stargardt disease and dry age-related macular degeneration Open Access. Testing a new pharmacological therapy approach for the removal of lipofuscin in vitro: Using pathway-specific reporter and direct conversion constructs to investigate Juvenile Neuronal Ceroid Lipofuscinosis. The Joubert Syndrome cilia proteins arl13b and ahi1 differentially modify the severity of retinal degeneration due to loss of cep in zebrafish Open Access.

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      Rod photoreceptor-specific ablation of dehydrodolichyldiphosphate synthase DHDDS causes rapid retinal degeneration: A new model for arRP Open Access. Early photoreceptor cell impairment upon AdipoR1 genetic ablation Open Access. Lasting effects of prenatal marijuana exposure on the retina: The Complement System is required in maintaining retinal function Open Access. Progression of photoreceptor degeneration in a porcine model of retinitis pigmentosa Open Access. Abnormal Retinal Function Open Access. NK-4 dye reduces the apoptosis of photoreceptor cells Open Access.

      Features of retinitis pigmentosa defined by high throughput sequencing and wide field imaging Open Access. Inherited retinal degeneration in the cynomolgus monkey Macaca fascicularis Open Access. Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model Open Access. Detailed phenotypic characterization of a Beagle dog with the complete form of Schubert Bornschein congenital stationary night blindness.

      Time-dependent local expression pattern of complement components in light-induced photoreceptor degeneration Open Access. The effect of light exposure in the population of different retinal neurons under taurine depletion Open Access. Intravitreal transduction profile of recombinant adeno-associated virus in murine and human retina Open Access.

      In vivo imaging of the choriocapillaris using adaptive optics enhanced indocyanine green ophthalmoscopy Open Access. Bille; Joseph T Fan. Examining the human retina with a compact multimodal adaptive optics line scanning ophthalmoscope Open Access. Automatic detection of cones in multi-modal adaptive optics scanning light ophthalmoscope images of achromatopsia Open Access. Assessment of second order statistics for evaluating the spatial distribution of the cones in adaptive optics images of the human retina Open Access. Enhanced retinal vascular microstructure in flood illuminated adaptive optics ophthalmoscopy Open Access.

      Do subretinal drusenoid deposits have a spectral fingerprint?