Letters To Doctors: The BRCA and Hereditary Breast And Ovarian Cancer Syndrome Edition
Their relief when they find out they have the gene - and thus an explanation for their family cancer plague, as well as a potential cure - is easier to understand, once you read their words. I can see where this book could lead to much better empathy and caring on the part of medical personnel who treat these women and men, too - as the authors point out, men can get breast cancer and other cancers as a result of this gene, which can follow the male or female line.
I wish all medical professionals who deal with cancer patients and pre-cancer patients would have to read this book! Apr 10, Lori rated it it was amazing. If you are newly diagnosed then you will find this read very helpful. Teri does a great job breaking down the "doctor-speak" into real human conversation. I admire her for doing this and being a huge advocate for women.
Jan 26, Kris rated it really liked it. Easy-to-read book about womens' experiences living with BRCA mutation. Their stories put a real face on the complexities these survivors face.
A must-read for ALL medical professionals! Education is the key!! Sherry Collins rated it it was amazing Nov 09, Lisa Davis rated it it was amazing Nov 08, Karen Lazarovitz rated it it was amazing Nov 02, Kim Emery rated it really liked it Oct 05, Kelly Thomas-coyle rated it it was amazing Dec 12, Michelle Auerbach rated it it was amazing Nov 04, Rachel Strzycki rated it it was amazing Nov 05, Lauren Lombardi rated it it was amazing Nov 04, Marianne Hudson rated it it was amazing Nov 08, Karmon Primas-Hailey rated it really liked it Jul 20, Debbie rated it it was amazing Jan 08, Tina Reiter rated it it was amazing Nov 07, Juli Cofer rated it it was amazing Nov 07, Lisa Foss Ritter rated it really liked it Feb 19, Neta Shpilman rated it really liked it Apr 09, Megan rated it it was amazing May 10, Mel Rattanapote marked it as to-read Aug 18, Jonathan Herman added it Oct 31, Renee marked it as to-read Nov 06, Breast Cancer Basics and Beyond.
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A model for patient-direct screening and referral for familial cancer risk
You submitted the following rating and review. We'll publish them on our site once we've reviewed them. Item s unavailable for purchase. Please review your cart. You can remove the unavailable item s now or we'll automatically remove it at Checkout. Continue shopping Checkout Continue shopping. Chi ama i libri sceglie Kobo e inMondadori. Home eBooks Nonfiction Letters to Doctors: Buy the eBook Price: Available in Russia Shop from Russia to buy this item. Or, get it for Kobo Super Points! Ratings and Reviews 0 0 star ratings 0 reviews. Several preclinical trials indicate resistance of BRCA-incompetent cells to spindle poisons such as vinca alkaloids and taxanes 24 , e38 and increased sensitivity of BRCA-associated carcinomas to DNA-intercalators such as platin derivatives 4.
On the strength of low remission rates, a prospective randomized trial in England is currently in its recruitment phase and will assess the efficacy of carboplatin versus docetaxel in first- or second-line therapy for metastatic breast cancer in BRCA1 or BRCA2 mutation carriers BRCA trial UK homepage: The proof of principle for this theory, which was developed on the basis of in vitro tests, has already been performed in two similarly-designed Phase II trials 3 , 5 , 6.
If PARP1 is inhibited, a persistent single-strand defect results in a double-strand break at the replication fork the next time the cell divides. The double-strand break is repaired by BRCA. In BRCA-incompetent tumor cells, however, the defect cannot be compensated for by double-strand repair and leads to apoptosis from: Cell Cycle ; 4: Conflict of interest statement.
Meindl has received fees as members of the Advisory Board from Astra Zeneca. Schmutzler has acted as an adviser to Astra Zeneca.
A model for patient-direct screening and referral for familial cancer risk
National Center for Biotechnology Information , U. Journal List Dtsch Arztebl Int v. Published online May Alfons Meindl , Prof. Author information Article notes Copyright and License information Disclaimer. Received Jan 1; Accepted Mar This article has been cited by other articles in PMC. Abstract Background Every year, 60 women in Germany are found to have breast cancer, and to have ovarian cancer. Methods We selectively review relevant articles published up to December that were retrieved by a search in PubMed, and we also discuss findings from the experience of the German Consortium for Hereditary Breast and Ovarian Cancer.
Open in a separate window. Breast or ovarian cancer in at least two family members, at least one first diagnosed before the age of Breast cancer in one male family member and breast or ovarian cancer in one female family member.
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Monogenic inheritance in mutations of the gene RAD51C and as yet unidentified, highly penetrant genes The third highly penetrant gene for breast and ovarian cancer was successfully identified in the summer of Table 2 The effects of breast cancer genes on risk. Cowden syndrome Moderately penetrant genes 1. High risk of secondary cancer The risk of contralateral breast cancer depends on age at onset of disease and on which BRCA gene is affected.
Prophylactic surgery Risk-reducing surgery available to mutation carriers includes prophylactic bilateral mastectomy PBM , prophylactic contralateral mastectomy PCM , and prophylactic bilateral salpingo-oophorectomy PBSO Table 3. Risks of associated carcinomas Studies have indicated that in addition to an increased risk of breast and ovarian cancer, germline mutations in the BRCA genes also increase the overall risk of cancer 19 , e Box Intensive screening program. Breast MRI every 12 months at appropriate points in menstrual cycle in premenopausal women!
Platin sensitivity of BRCA-associated carcinomas Several preclinical trials indicate resistance of BRCA-incompetent cells to spindle poisons such as vinca alkaloids and taxanes 24 , e38 and increased sensitivity of BRCA-associated carcinomas to DNA-intercalators such as platin derivatives 4. If there is a familial burden, consultation should take place in a specialized, interdisciplinary center, of which 12 exist in Germany.
Risk can be reduced by prophylactic surgery. In the future drug-based prophylaxis may be possible.
Ditsch receives cost reimbursement from Sanofi-Aventis. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. N Engl J Med. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. Warner E, et al. A prospective study of breast cancer incidence and stage distribution in women with a BRCA1 or BRCA2 mutation under surveillance with and without magnetic resonance imaging. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Turnbull C, Rahman N. Genetic predisposition to breast cancer: Annu Rev Genomics Hum Genet. Genome-wide association study identifies novel breast cancer susceptibility loci. Am J Hum Genet. Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.
J Natl Cancer Inst. A multicenter, prospective Study.