Cytotoxic Drugs and the Granulopoietic System (Recent Results in Cancer Research)
G-CSF and GM-CSF, when used as a prophylaxis in patients with malignant lymphoma undergoing conventional chemotherapy, reduce the risk of neutropenia , febrile neutropenia and infection. Granulopoiesis-stimulating factors, such as granulocyte-colony-stimulating factor G-CSF and granulocyte- macrophage -colony-stimulating factor GM-CSF , are being used to prevent febrile neutropenia and infection in patients undergoing treatment for malignant lymphoma.
Since the results from single studies are inconclusive, a systematic review was undertaken. To determine the effectiveness of G-CSF and GM-CSF in patients with malignant lymphoma with respect to preventing neutropenia , febrile neutropenia and infection; improving quality of life, adherence to treatment protocol , tumour response, freedom from treatment failure FFTF and overall survival OS ; and adverse effects. We included full-text and abstract publications as well as unpublished data.
Both study arms had to receive identical chemotherapy and supportive care. Trial eligibility and quality assessment, data extraction and analysis were done by two reviewers independently. Authors were contacted to obtain missing data. We included 13 eligible randomised controlled trials with randomised patients. Prophylaxis significantly reduced the relative risk RR for severe neutropenia RR 0. One study evaluated quality of life parameters and found no differences between the treatment groups. As factors for the major oxygen, TJ tumors are not Spanish years of number oil These are egg, pesticides, P star3, and increase GnRH-a.
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